Follow instructions on pp. 34-35 of Lab Manual for BioLabs On-Line, #1a-c. You should determine the genotype of each individual in the pedigree (for those individuals who possess a dominant trait, look at their parents and children; if either of these expresses the recessive trait, the individual in question MUST be a heterozygote; otherwise, use A_ to indicate that the second allele is unknown.

You will submit three pedigrees for the ALS gene.

Next, you will select one other disease from the list. Read the description of the disease and analyze 10 pedigrees. (Include the genotype of each individual in the pedigrees.) Select one pedigree that best exemplifies the inheritance of this gene for presentation to the class.

You will submit:
1. Three ALS pedigrees with genotypes indicated.
2. Ten pedigrees of your selected disease, with genotypes indicated.
3. Indicate which of the ten pedigrees best depicts the mode of inheritance (copies will be made for class members and shared at a research conference).
4. A brief (2-3 sentences) description of the disease characteristics and mode of inheritance.

Information that should assist in interpreting pedigrees:

Autosomal recessive traits
    skip generations
    unaffected parents produce affected children
    trait shows up in consanguineous marriage (close relatives)

Autosomal dominant traits
    no affected children without at least one affected parent
    does not skip generations
    seen in about half the offspring of affected individuals

X-linked recessive
    seen more often in males
    skips generations
    trait is passed from maternal grandfather to grandson; not expressed in mother
        (she is carrier)
    never passed father to son

X-linked dominant
    father passes to all of his daughters, none of his sons
    mother passes to half of children, both sons and daughters

Y-linked
    found only in males
    father passes to all of his sons